I am a Ph.D. student in the Molecular, Cellular, and Integrative Biosciences (MCIBS) program in the Department of Biology at the Pennsylvania State University. My research interest mainly lies in the field of understanding structure-function relationship. I am interested in computational biology and genomics. My current doctoral project involves research on evolutionary and genomic basis of non-B-DNA structures, focusing specifically on G-quadruplexes (or G4s) under the supervision of Prof. Kateryna D. Makova.

I obtained my dual Bachelor's and Master's degree (BS-MS) in Biological Sciences from Indian Institute of Science Education and Research (IISER) Kolkata, India in 2022. Through my Master's thesis, I worked under Dr. Susmita Roy investigating the drug-mediated conformational changes in KRas–a protein involved in the Ras/Raf/MAPK pathway. I used Molecular Dynamics simulations and free-energy based enhanced sampling techniques (Metadynamics) to study the effects of the two drugs: Sotorasib (AMG510) and Adagrasib (MRTX849).


Saswat Kumar Mohanty

Ph.D. student

Department of Biology

The Pennsylvania State University

311 Wartik Laboratory, University Park, PA, 16802